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The star-allele nomenclature: retooling for translational genomics.

Robarge JD, Li L, Desta Z, Nguyen A, Flockhart DA

Division of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA. jrobarge@iupui.edu

The star-allele nomenclature is the result of efforts to standardize genetic polymorphism annotation for the cytochrome P450 genes. As clinical pharmacogenetic testing becomes widespread, it is important that this system effectively communicate a patient's genotype and predicted clinical phenotype. As genomics research expands, it is equally important that the system remain a valuable tool for the wider community of genetic researchers to exploit our ever-improving ability to catalog variability in the human genome.

Published 16 August 2007 in Clin Pharmacol Ther, 82(3): 244-8.
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