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Effect of transcranial magnetic stimulation on action naming in patients with Alzheimer disease.

Cotelli M, Manenti R, Cappa SF, Geroldi C, Zanetti O, Rossini PM, Miniussi C

Istituto di Recovero e Cura a Carattere Scientifico San Giovanni di Dio Fatebenefratelli, University of Brescia, Brescia, Italy.

OBJECTIVE: To assess the effect of repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) on picture naming in patients with Alzheimer disease (AD). DESIGN: Experimental study. Patients with AD underwent rTMS in real and control conditions during picture-naming tasks. SETTING: San Giovanni di Dio Fatebenefratelli Scientific Institute in Brescia, Italy. Patients Fifteen patients with probable AD. Intervention High-frequency rTMS was applied to the left and right DLPFC during object and action naming. MAIN OUTCOME MEASURES: Language ability was assessed by accuracy of verbal response during online rTMS. RESULTS: Stimulation to the left and right DLPFC improved accuracy in action naming. CONCLUSIONS: These findings indicate that rTMS to the DLPFC, which speeds up action naming in normal controls, improves performance in patients with AD. While the mechanisms of rTMS-induced naming facilitation in these patients are unknown, the procedure may be worth testing as a novel approach to the treatment of language dysfunction.

Published 14 November 2006 in Arch Neurol, 63(11): 1602-4.
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